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Article

Inferring the paths of somatic evolution in cancer.

Bioinformatics (Oxford, England) - 1 Sept 2014

Misra Navodit, Szczurek Ewa, Vingron Martin

Abstract excerpt

MOTIVATION: Cancer cell genomes acquire several genetic alterations during somatic evolution from a normal cell type. The relative order in which these mutations accumulate and contribute to cell fitness is affected by epistatic interactions. Inferring their evolutionary history is challenging because of the large number of mutations acquired by cancer cells as well as the presence of unknown epistatic...

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PMID: 24812340
DOI: 10.1093/bioinformatics/btu319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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