Article
The activity of 4CMB, 4HMB and BC in Saccharomyces cerevisiae JD1.
Mutation research - 1 Jan 2000
Wilcox P, Parry J M
Abstract excerpt
3 structurally related compounds, 4-chloromethylbiphenyl (4CMB), 4-hydroxymethylbiphenyl (4HMB), and benzyl chloride (BC) were assayed for their ability to induce mitotic gene conversion in stationary phase cultures of the yeast, Saccharomyces cerevisiae JD1. This strain allows gene conversion to be scored at 2 independent loci, trp 5 and his 4. The results reported in this paper indicate that both 4CMB and BC...
Topics
- Animals
- Benzyl Compounds
- Biotransformation
- Biphenyl Compounds
- Male
- Microsomes, Liver
- Mutagenicity Tests
- Mutagens
- Mutation
- Rats
- Saccharomyces cerevisiae
- Structure-Activity Relationship
