Article
Mutant yields and mutational spectra of the heterocyclic amines MeIQ and PhIP at the S1 locus of human-hamster AL cells with activation by chick embryo liver (CELC) co-cultures.
Mutation research - 10 Mar 1999
Waldren C A, Ueno A M, Schaeffer B K, Wood S G, Sinclair P R, Doolittle D J, Smith C J, Harvey W F, Shibuya M L, Gustafson D L, Vannais D B, Puck T T, Sinclair J F
Abstract excerpt
Cooking meat and fish at high temperature creates heterocyclic amines (HA) including 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Several HA are mutagens in the Ames' S9/Salmonella assay. While PhIP is a substantial Ames' test mutagen, it is 1000-fold less active than the extraordinarily potent MeIQ. In contrast, MeIQ is significantly less...
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