Article

Sigma receptor ligands are potent anti-prion compounds that act independently of sigma receptor binding

2023-11-29

Abstract excerpt

Prion diseases are invariably fatal neurodegenerative diseases of humans and other animals for which there are no treatment options. Previous work from our laboratory identified phenethyl piperidines as novel class of anti-prion compounds. While working to identify the molecular target(s) of these molecules, we unexpectedly discovered ten novel anti-prion compounds based on their known ability to bind to the sigma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e84e74df-17f2-512f-9e0a-3d5d0621499a
DOI: 10.1101/2023.11.28.569035

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sigma receptor ligands are potent anti-prion compounds that act independently of sigma receptor bindingDOI 10.1101/2023.11.28.569035Read

Emerging Benefits: Pathophysiological Functions and Target Drugs of the Sigma-1 Receptor in Neurodegenerative DiseasesSemantic proximity Read

Role of sigma-1 receptors in neurodegenerative diseasesSemantic proximity Read

Approaches for discovering anti-prion compounds: lessons learned and challenges ahead.Semantic proximity Read

Anti-Prion Activity of Brilliant Blue GSemantic proximity Read

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.Semantic proximity Read

Therapeutic strategies for identifying small molecules against prion diseasesSemantic proximity Read

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.Semantic proximity Read

Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian PrionsSemantic proximity Read

Discovery of 2-Aminothiazoles as Potent Antiprion CompoundsSemantic proximity Read

Pridopidine modifies disease phenotype in a SOD1 mouse model of amyotrophic lateral sclerosis.Semantic proximity Read

Quinacrine promotes replication and conformational mutation of chronic wasting disease prions.Semantic proximity Read

Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein.Semantic proximity Read