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Article

Pridopidine modifies disease phenotype in a SOD1 mouse model of amyotrophic lateral sclerosis.

The European journal of neuroscience - 1 Mar 2022

Estévez-Silva Héctor M, Mediavilla Tomás, Giacobbo Bruno Lima, Liu Xijia, Sultan Fahad R, Marcellino Daniel J

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a lethal and incurable neurodegenerative disease due to the loss of upper and lower motor neurons, which leads to muscle weakness, atrophy, and paralysis. Sigma-1 receptor (σ-1R) is a ligand-operated protein that exhibits pro-survival and anti-apoptotic properties. In addition, mutations in its codifying gene are linked to development of juvenile ALS pointing to an important...

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PMID: 35080077
DOI: 10.1111/ejn.15608
PMCID: PMC9305776

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