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Article

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.

Neurobiology of disease - 1 Feb 2014

Peviani Marco, Salvaneschi Eleonora, Bontempi Leonardo, Petese Alessandro, Manzo Antonio, Rossi Daniela, Salmona Mario, Collina Simona, Bigini Paolo, Curti Daniela

Abstract excerpt

The identification of novel molecular targets crucially involved in motor neuron degeneration/survival is a necessary step for the development of hopefully more effective therapeutic strategies for amyotrophic lateral sclerosis (ALS) patients. In this view, S1R, an endoplasmic reticulum (ER)-resident receptor with chaperone-like activity, has recently attracted great interest. S1R is involved in several processes...

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Source

Identifiers

PMID: 24141020
DOI: 10.1016/j.nbd.2013.10.010

Genes

SOD1
BDNF
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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