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Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions

22 Apr 2008

Abstract excerpt

BACKGROUND: Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans. METHODOLOGY/PRINCIPAL FINDINGS: Here we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-adrenergic receptors routinely used in human medicine as an antihypertensive drug. We isolated GA in a screen for drugs active in vivo against two different yeast...

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PMID: 18431471
DOI: 10.1371/journal.pone.0001981

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