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Article

Human NKX2.2 influences islet endocrine cell fate choices through regulation of WNT pathway genes

2025-09-28

Abstract excerpt

<h4>SUMMARY</h4> Transcriptional regulation is a key central mechanism of cell fate determination in developing tissues. The homeobox transcription factor NKX2.2 is an essential regulator of mouse and human pancreatic endocrine development, however its precise molecular role in a human system has not been previously investigated. In this study we generated NKX2.2 null (NKX2.2KO) human embryonic stem cell (hESC) l...

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Identifiers and source

Literature Corpus work
e83443e8-927a-502c-a3b7-66cdf87a6bc0
DOI
10.1101/2025.09.26.677825
Open publication

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Human NKX2.2 influences islet endocrine cell fate choices through regulation of WNT pathway genesDOI 10.1101/2025.09.26.677825
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