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Article

The Role of ARX in Human Pancreatic Endocrine Specification

3 Dec 2015

Abstract excerpt

The in vitro differentiation of human embryonic stem cells (hESCs) offers a model system to explore human development. Humans with mutations in the transcription factor Aristaless Related Homeobox (ARX) often suffer from the syndrome X-linked lissencephaly with ambiguous genitalia (XLAG), affecting many cell types including those of the pancreas. Indeed, XLAG pancreatic islets lack glucagon and pancreatic...

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PMID: 26633894
DOI: 10.1371/journal.pone.0144100

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