Article
Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.
Developmental biology - 15 Dec 2007
Chao Christina S, Loomis Zoe L, Lee Jacqueline E, Sussel Lori
Abstract excerpt
Nkx2.2 and NeuroD1 are vital for proper differentiation of pancreatic islet cell types. Nkx2.2-null mice fail to form beta cells, have reduced numbers of alpha and PP cells and display an increase in ghrelin-producing epsilon cells. NeuroD1-null mice display a reduction of alpha and beta cells after embryonic day (e) 17.5. To begin to determine the relative contributions of Nkx2.2 and NeuroD1 in islet...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cell Differentiation
- Embryo, Mammalian
- Gene Expression Regulation, Developmental
- Ghrelin
- Glucagon
- Glucagon-Secreting Cells
- Homeobox Protein Nkx-2.2
- Homeodomain Proteins
- Islets of Langerhans
- Mice
- Mice, Knockout