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Article

Distinct Gene Expression Programs Function in Progenitor and Mature Islet Cells

1 May 2003

Abstract excerpt

Homeodomain transcription factor Nkx2.2 is required for the final differentiation of the beta-cells in the pancreas and for the production of insulin. Nkx2.2 is expressed in islet cell precursors during pancreatic development and persists in a subset of mature islet cells including all beta-cells. To understand the mechanisms regulating the expression of Nkx2.2 in these different cell populations, we outlined the...

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PMID: 12604598
DOI: 10.1074/jbc.m213196200

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