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Article

The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.

Development (Cambridge, England) - 15 Jul 2016

Gross Stefanie, Garofalo Diana C, Balderes Dina A, Mastracci Teresa L, Dias José M, Perlmann Thomas, Ericson Johan, Sussel Lori

Abstract excerpt

Intestinal hormone-producing cells represent the largest endocrine system in the body, but remarkably little is known about enteroendocrine cell type specification in the embryo and adult. We analyzed stage- and cell type-specific deletions of Nkx2.2 and its functional domains in order to characterize its role in the development and maintenance of enteroendocrine cell lineages in the mouse duodenum and colon....

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Identifiers

PMID: 27287799
DOI: 10.1242/dev.130682
PMCID: PMC4958331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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