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Article

Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency

20 Jan 2021

Abstract excerpt

Abstract FOXA2 has been identified as an essential factor for pancreas development and emerging evidence supports an association between FOXA2 and diabetes. Although the role of FOXA2 during pancreatic development is well-studied in animal models, its role during human islet cell development remains unclear. Here, we generated induced pluripotent stem cells (iPSCs) from a patient withFOXA2haploinsufficiency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33473118
DOI: 10.1038/s41419-021-03390-8

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