Article

TAK1 regulates skeletal muscle mass, hypertrophic signaling, and metabolic homeostasis in male and female mice

2026-02-28

Abstract excerpt

Skeletal muscle is the most abundant tissue in the human body and is essential for locomotion and the regulation of whole-body metabolism. The maintenance of skeletal muscle mass is essential for health, yet the molecular and signaling mechanisms that control skeletal muscle mass remain poorly understood. Transforming growth factor-β-activated kinase 1 (TAK1) is a key signaling protein that regulates multiple intr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e82af1e7-6c4c-513c-8530-12d82460aa71
DOI: 10.64898/2026.02.26.708345

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TAK1 regulates skeletal muscle mass, hypertrophic signaling, and metabolic homeostasis in male and female miceDOI 10.64898/2026.02.26.708345Read

Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics.Semantic proximity Read

TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways.Semantic proximity Read

lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy.Semantic proximity Read

The utility of the rodent synergist ablation model in identifying molecular and cellular mechanisms of skeletal muscle hypertrophySemantic proximity Read

Exercise ameliorates sarcopenia and metabolic dysfunction–associated steatohepatitis through activation of skeletal muscle PGC-1α/SIRT1 signaling in miceSemantic proximity Read

<scp>SRT</scp>2104 extends survival of male mice on a standard diet and preserves bone and muscle massSemantic proximity Read

The AMPK-related kinase SNARK regulates muscle mass and myocyte survivalSemantic proximity Read

The JAK/STAT Pathway in Skeletal Muscle PathophysiologySemantic proximity Read

Temporal regulation of TAK1 to counteract muscular dystrophySemantic proximity Read

Signalling pathways that mediate skeletal muscle hypertrophy and atrophySemantic proximity Read

The Hippo signal transduction network for exercise physiologistsSemantic proximity Read

Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia.Semantic proximity Read