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Article

Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics.

The Journal of clinical investigation - 11 Jun 2024

Kerr Haiming L, Krumm Kora, Anderson Barbara, Christiani Anthony, Strait Lena, Li Theresa, Irwin Brynn, Jiang Siyi, Rybachok Artur, Chen Amanda, Dacek Elizabeth, Caeiro Lucas, Merrihew Gennifer E, MacDonald James W, Bammler Theo K, MacCoss Michael J, Garcia Jose M

Abstract excerpt

Our study was to characterize sarcopenia in C57BL/6J mice using a clinically relevant definition to investigate the underlying molecular mechanisms. Aged male (23-32 months old) and female (27-28 months old) C57BL/6J mice were classified as non-, probable-, or sarcopenic based on assessments of grip strength, muscle mass, and treadmill running time, using 2 SDs below the mean of their young counterparts as cutoff...

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Identifiers

PMID: 39145448
DOI: 10.1172/JCI172890
PMCID: PMC11324300

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