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Article

The Hippo signal transduction network for exercise physiologists

4 Mar 2016

Abstract excerpt

The ubiquitous transcriptional coactivators Yap (gene symbol Yap1) and Taz (gene symbol Wwtr1) regulate gene expression mainly by coactivating the Tead transcription factors. Being at the center of the Hippo signaling network, Yap and Taz are regulated by the Hippo kinase cassette and additionally by a plethora of exercise-associated signals and signaling modules. These include mechanotransduction, the AKT-mTORC1...

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PMID: 26940657
DOI: 10.1152/japplphysiol.01076.2015

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