Article

Direct ionic stress sensing and mitigation by the transcription factor NFAT5

2023-09-24

Abstract excerpt

<h4>SUMMARY</h4> Homeostatic control of intracellular ionic strength is essential for protein, organelle and genome function, yet mechanisms that sense and enable adaptation to ionic stress remain poorly understood in animals. We find that the transcription factor NFAT5 directly senses solution ionic strength using a C-terminal intrinsically disordered region. Both in intact cells and in a purified system, NFAT5...

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Literature Corpus work: e3bb1826-315d-5f04-a4f3-95b4f9eb3e75
DOI: 10.1101/2023.09.23.559074

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