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Article

Mutations that reduce its specific DNA binding inhibit high NaCl-induced nuclear localization of the osmoprotective transcription factor NFAT5.

American journal of physiology. Cell physiology - 15 Nov 2012

Izumi Yuichiro, Li Jinxi, Villers Courtney, Hashimoto Kosuke, Burg Maurice B, Ferraris Joan D

Abstract excerpt

The transcription factor nuclear factor of activated T cell 5 (NFAT5) is activated by the stress of hypertonicity (e.g., high NaCl). Increased expression of NFAT5 target genes causes accumulation of protective organic osmolytes and heat shock proteins. Under normotonic conditions (∼300 mosmol/kgH...

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Source

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Identifiers

PMID: 22992674
DOI: 10.1152/ajpcell.00265.2012
PMCID: PMC3492838

Genes

NFAT5
NUP88
XPO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22992674-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Mutations that reduce its specific DNA binding inhibit high NaCl-induced nuclear localization of the osmoprotective transcription factor NFAT5.PMID 22992674Read ↗

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NFAT5 in cellular adaptation to hypertonic stress – regulations and functional significanceSemantic proximity Read ↗

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