Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus

15 Sept 2020

Abstract excerpt

B family member, is the only known gene regulator of the mammalian adaptive response to osmotic stress. Exposure to elevated glucose increases the expression and nuclear translocation of NFAT5, as well as NFAT5-driven transcriptional activity in vivo and in vitro. Increased expression of NFAT5 is closely correlated with the progression of diabetes in patients. The distinct structure of NFAT5 governs its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldose Reductase and Taurine
Share to Biochemical effects in animals

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33015193
DOI: 10.1155/2020/6927429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes MellitusPMID 33015193Read ↗

NFAT5 in cellular adaptation to hypertonic stress – regulations and functional significanceSemantic proximity Read ↗

NFAT5 Confers Differential Expression in Innate Immune Cells vs. Renal Epithelial Cells in the Face of Osmotic StressSemantic proximity Read ↗

Transcription factors in the pathophysiology of diabetes mellitus.Semantic proximity Read ↗

Diabetes Induced Renal Complications by Leukocyte Activation of Nuclear Factor κ-B and its Regulated Genes ExpressionSemantic proximity Read ↗

Role of transcription factor FOXM1 in diabetes and its complications (Review)Semantic proximity Read ↗

ACP5: Its Structure, Distribution, Regulation and Novel FunctionsSemantic proximity Read ↗

Inflammation-related gene ITGA5 affects the healing of diabetic foot ulcers through PI3K-AKT signaling pathwaySemantic proximity Read ↗

Identification of transcription factors related to diabetic tubulointerstitial injurySemantic proximity Read ↗

NFAT Gene Family in Inflammation and CancerSemantic proximity Read ↗

Role of Transcription Factor NFAT in Glucose and Insulin HomeostasisSemantic proximity Read ↗

Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication.Semantic proximity Read ↗

HES1 contributes to high salt stress response as an enhancer of NFAT5-DNA bindingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.