Article

Assessing the helical stability of polyXYs at the boundaries of Intrinsically Disordered Regions with MD simulations

2024-11-18

Abstract excerpt

Intrinsically disordered regions (IDRs) in proteins lack stable structure. By carrying many hydrophilic and charged residues, it prevents them from forming globular domains and contributes to their flexibility and accessibility. Naturally, regions with reduced amino acid composition (low complexity regions; LCRs) occur within IDRs. Disorder and low complexity in protein sequences are linked to various biological f...

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Literature Corpus work: d36060ee-c5e3-5d44-a1a1-33a72f5ec6f6
DOI: 10.1101/2024.11.16.623902

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