Article

HyRes: Accurate Physics-Based Simulation of Dynamic Protein Structures and Interactions in Complex Environments at Scale

2026-06-24

Abstract excerpt

Intrinsically disordered proteins and regions (IDPs) are ubiquitous cellular regulators. Uncovering how their transient, multivalent interactions organize and fine-tune cellular processes requires transferable methods capable of deriving dynamic conformational ensembles across diverse environments at scale. Here, we present HyRes, a physics-based, hybrid-resolution protein model with atomistic backbones and interm...

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Literature Corpus work: 216d6232-f225-5aee-abe5-bb87b3a1fdcc
DOI: 10.64898/2026.06.23.734133

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