Article

AF-CALVADOS: AlphaFold-guided simulations of multi-domain proteins at the proteome level

2025-10-19

Abstract excerpt

Deep-learning methods have transformed our ability to predict the three-dimensional structures of folded proteins from sequence, and coarse-grained simulations have made it possible to study intrinsically disordered proteins at the proteome scale. More than half of human proteins, however, contain mixtures of disordered regions and one or more folded domains, and the biological function of these multi-domain prote...

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Literature Corpus work: 9654e19f-9013-5aad-a993-a7de50f3bc49
DOI: 10.1101/2025.10.19.683306

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