Article

Effects of substrate stiffness and actin velocity on <i>in silico</i> fibronectin fibril morphometry and mechanics

2021-02-24

Abstract excerpt

Assembly of the extracellular matrix protein fibronectin (FN) into insoluble, viscoelastic fibrils is a critical step during embryonic development and wound healing; misregulation of FN fibril assembly has been implicated in many diseases, including fibrotic diseases and cancer. We have previously developed a computational model of FN fibril assembly that recapitulates the morphometry and mechanics of cell-derived...

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Identifiers and source

Literature Corpus work: e7ee79a5-4198-5573-92dd-4daeac814a71
DOI: 10.1101/2021.02.24.432650

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