Rigidity Sensing of Inclusions Directs Differentiated Cell Elongation and Force Generation across Phenotypes.

Abstract excerpt

Fibrosis is driven in part by the transition of healthy fibroblasts to a contractile phenotype called myofibroblasts. The mechanics of the extracellular matrix play a crucial role in regulating cell fates and behaviors during this transition. However, most studies to date focus on cells grown on 2D surfaces and matrices with homogeneous properties. This leaves open how local rigidity differentially regulates the...

Topics

• Myofibroblasts
• Phenotype
• Cell Differentiation
• Collagen
• Humans
• Fibroblasts
• Animals