Article

Topology of connective tissues: a key parameter in cellular heterogeneity, beyond composition and stiffness

2022-01-28

Abstract excerpt

Cellular plasticity is essential in physiological contexts, including pathological ones. It is the basis of morphogenesis and organogenesis, as well as tumorigenesis and metastasis. The extracellular matrix (ECM) is a key player in the generation of cellular heterogeneity. Advances in our understanding of cell plasticity rely on our ability to provide relevant in vitro models. This requires to catch the character...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41ce0be2-8633-50e7-800a-419e67cfbeea
DOI: 10.1101/2022.01.26.477902

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Topology of connective tissues: a key parameter in cellular heterogeneity, beyond composition and stiffnessDOI 10.1101/2022.01.26.477902Read

Complex mechanics of the heterogeneous extracellular matrix in cancerSemantic proximity Read

The biology of the extracellular matrixSemantic proximity Read

Fibrillin microfibrils: connective tissue pathways that regulate shape and signaling.Semantic proximity Read

The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systemsSemantic proximity Read

Complexity of matrix phenotypesSemantic proximity Read

Cell based strain stiffening of a non-fibrous matrix as organizing principle for morphogenesisSemantic proximity Read

Architectural Dynamics in Living Tissues: Integrating Structure, Physical Fields and Spatial NetworksSemantic proximity Read

Engineering the Extracellular Matrix to Model the Evolving Tumor MicroenvironmentSemantic proximity Read

The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks.Semantic proximity Read

Physical network regimes of 3D fibrillar collagen networks trigger invasive phenotypes of breast cancer cells.Semantic proximity Read

Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cellsSemantic proximity Read

EDA Fibronectin Microarchitecture and YAP Translocation during Wound ClosureSemantic proximity Read