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Article

SOX4 reversibly induces phenotypic changes by suppressing the epithelial marker genes in human keratinocytes.

Molecular biology reports - 16 Jan 2024

Nagaoka Yoshiyuki, Takeishi Yukimasa, Miyake Yuki, Takeda Kana, Okamura Kazuhiko, Yao Yuan, Motomura Kaori, Daitoku Hiroaki, Fukamizu Akiyoshi, Hatta Mitsutoki

Abstract excerpt

BACKGROUND: SOX4 is a transcription factor belonging to the SOX (Sry-related High Mobility Group [HMG] box) family and plays a pivotal role in various biological processes at various stages of life. SOX4 is also expressed in the skin in adults and has been reported to be involved in wound healing, tumor formation, and metastasis. METHODS AND RESULTS: In this study, we investigated the role of SOX4 in keratinocyte...

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PMID: 38227121
DOI: 10.1007/s11033-023-09035-7

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