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Stem Cell Marker OCT3/4 in Tumor Biology and Germ Cell Tumor Diagnostics: History and Future

1 Jan 2006

Abstract excerpt

The transcription factor OCT3/4 (also known as POU5F1 and Oct4) is regarded as one of the key regulators of pluripotency. Expression in nonmalignant cells is restricted to the pluripotent cells in the embryo and the primordial germ cells that will pass pluripotency to future generations via the gametes. Although major progress has been made in successfully identifying other players in the pluripotency network by...

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PMID: 17425502
DOI: 10.1615/critrevoncog.v12.i3-4.10

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