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Article

Architectural niche organization by LHX2 is linked to hair follicle stem cell function.

Cell stem cell - 5 Sept 2013

Folgueras Alicia R, Guo Xingyi, Pasolli H Amalia, Stokes Nicole, Polak Lisa, Zheng Deyou, Fuchs Elaine

Abstract excerpt

In adult skin, self-renewing, undifferentiated hair follicle stem cells (HF-SCs) reside within a specialized niche, where they spend prolonged times as a single layer of polarized, quiescent epithelial cells. When sufficient activating signals accumulate, HF-SCs become mobilized to fuel tissue regeneration and hair growth. Here, we show that architectural organization of the HF-SC niche by transcription factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24012369
DOI: 10.1016/j.stem.2013.06.018
PMCID: PMC3856689

Genes

LHX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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