Discovery of a tRNA-regulatory transcription factor that suppresses breast cancer metastasis

Abstract excerpt

Transfer RNAs (tRNAs), once viewed as static adaptors in translation, are now recognized as dynamic regulators of gene expression. While recent studies have illuminated roles for tRNA stability, the upstream mechanisms governing tRNA transcription remain poorly understood. To address this gap, we generated the EXpression atlas of tRNA (EXTRNA), a high-resolution tRNA expression dataset spanning 24 cell lines acros...

Topics

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• Anticodon
• Cluster Analysis
• MCF-7 Cells
• Nucleic Acid Conformation
• RNA
• RNA, Mitochondrial
• RNA modifications and cancer
• RNA, Transfer

Identifiers and source

Literature Corpus work

e7cd0a7c-dd77-53b8-a1ab-ca5955ca455d

DOI

10.1101/2025.04.26.650725