Article
Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer.
Genes - 22 Nov 2020
Wang Justin, Vallee Ingrid, Dutta Aditi, Wang Yu, Mo Zhongying, Liu Ze, Cui Haissi, Su Andrew I, Yang Xiang-Lei
Abstract excerpt
Aminoacyl-tRNA synthetases (aaRSs) are key enzymes in the mRNA translation machinery, yet they possess numerous non-canonical functions developed during the evolution of complex organisms. The aaRSs and aaRS-interacting multi-functional proteins (AIMPs) are continually being implicated in tumorigenesis, but these connections are often limited in scope, focusing on specific aaRSs in distinct cancer subtypes. Here,...
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