Article

Targeting tRNA-Arg-TCT-4-1 suppresses cancer cell growth and tumorigenesis

2026-02-20

Abstract excerpt

tRNAs play a critical role in protein synthesis, influencing mRNA translation dynamics to shape proteomes. Emerging evidence links dysregulated tRNA activity to cancer progression, with tRNA-Arg-TCT identified as an oncogenic driver when ectopically overexpressed in non-malignant cells. The requirement of endogenous tRNA-Arg-TCT in cancer biology, however, remains untested. Moreover, considering that the tRNA-Arg-...

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Literature Corpus work: 3fdd7180-fce4-561e-a51b-136feca659e6
DOI: 10.64898/2026.02.19.706891

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