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Genetic Control of tRNA-Derived Fragments Contributes to Cancer Risk.

Cancer research - 15 Oct 2025

Li Bin, Li Hanting, Li Yan, Chen Zhirui, Zou Danyi, He Chunyi, Li Songqiang, Hu Kexin, Ning Caibo, Li Yanmin, Geng Hui, Yang Shuhui, Huang Chaoqun, Yang Xiaojun, Wang Qiuhong, Zhu Xu, Li Xiangpan, Zhu Ying, Jin Meng, Miao Xiaoping, Tian Jianbo

Abstract excerpt

tRNA-derived fragments (tRF) are a class of small noncoding RNAs that have exhibited several functions in cancer. Recent studies have shown that mutations in tRNA genes can lead to global changes in tRF expression levels and may affect tRF function, highlighting the need to further elucidate the regulation and functions of tRFs in cancer. In this study, we conducted a pan-cancer analysis of tRF quantitative trait...

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PMID: 40773675
DOI: 10.1158/0008-5472.CAN-25-1282

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POU2F1

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