Article

ADAT2/3-mediated tRNA editing promotes cancer cell growth and tumorigenicity

2024-11-03

Abstract excerpt

Transfer RNAs (tRNAs) are subject to various chemical modifications that influence their stability or function. Adenosine to Inosine (A-to-I) editing in the tRNA anticodon at position A34 is an important modification that expands anticodon-codon recognition at the wobble position and is required for normal mRNA translation. The relevance of tRNA editing in cancer remains unexplored. Here we show that the genes enc...

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Literature Corpus work: ec2da712-5b9d-50fd-91ec-01c62de728ee
DOI: 10.1101/2024.10.31.621298

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