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Article

CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT

21 Nov 2016

Abstract excerpt

The importance of translational regulation in tumour biology is increasingly appreciated. Here, we leverage polyribosomal profiling to prospectively define translational regulatory programs underlying epithelial-to-mesenchymal transition (EMT) in breast epithelial cells. We identify a group of ten translationally regulated drivers of EMT sharing a common GU-rich cis-element within the 3'-untranslated region...

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PMID: 27869122
DOI: 10.1038/ncomms13362

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