Systems-level Analysis of 32 TCGA Cancers Reveals Disease-dependent tRNA Fragmentation Patterns and Very Selective Associations with Messenger RNAs and Repeat Elements

Abstract excerpt

We mined 10,274 datasets from The Cancer Genome Atlas (TCGA) for tRNA fragments (tRFs) that overlap nuclear and mitochondrial (MT) mature tRNAs. Across 32 cancer types, we identified 20,722 distinct tRFs, a third of which arise from MT tRNAs. Most of the fragments belong to the novel category of i-tRFs, i.e. they are wholly internal to the mature tRNAs. The abundances and cleavage patterns of the identified tRFs d...

Topics

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• Anticodon
• Cluster Analysis
• MCF-7 Cells
• Nucleic Acid Conformation
• RNA
• RNA, Mitochondrial
• RNA, Transfer
• Transcriptome

Identifiers and source

Literature Corpus work

3e9fe070-1ed6-5bf9-89f9-e4b2b55c95ac

DOI

10.1101/135517