Article

The IDH-Tau-EGFR triad defines diffuse glioma pathology by controlling mesenchymal differentiation and neo-vascular fitness

2019-02-07

Abstract excerpt

<h4>SUMMARY</h4> Classification of gliomas as wild-type or mutant IDH1/2 tumors has profound clinical implications. However, how these two groups of gliomas progress, in a microenvironment-dependent manner, is still a pending question. Here we describe that the expression of Tau is epigenetically induced by mutant IDH1/2, whereas is almost absent from tumors with EGFR/PTEN mutations. Moreover, Tau (MAPT) expre...

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Literature Corpus work: e7cc9d63-483f-53ea-859e-4f8e6206aee7
DOI: 10.1101/541326

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