Article
The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas.
Science translational medicine - 22 Jan 2020
Gargini Ricardo, Segura-Collar Berta, Herránz Beatriz, García-Escudero Vega, Romero-Bravo Andrés, Núñez Felipe J, García-Pérez Daniel, Gutiérrez-Guamán Jacqueline, Ayuso-Sacido Angel, Seoane Joan, Pérez-Núñez Angel, Sepúlveda-Sánchez Juan M, Hernández-Laín Aurelio, Castro María G, García-Escudero Ramón, Ávila Jesús, Sánchez-Gómez Pilar
Abstract excerpt
Gliomas that express the mutated isoforms of isocitrate dehydrogenase 1/2 (IDH1/2) have better prognosis than wild-type (wt) IDH1/2 gliomas. However, how these mutant (mut) proteins affect the tumor microenvironment is still a pending question. Here, we describe that the transcription of microtubule-associated protein TAU (MAPT), a gene that has been classically associated with neurodegenerative diseases, is...
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