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Article

Tumor-Derived Pericytes Driven by EGFR Mutations Govern the Vascular and Immune Microenvironment of Gliomas.

Cancer research - 15 Apr 2021

Segura-Collar Berta, Garranzo-Asensio María, Herranz Beatriz, Hernández-SanMiguel Esther, Cejalvo Teresa, Casas Bárbara S, Matheu Ander, Pérez-Núñez Ángel, Sepúlveda-Sánchez Juan Manuel, Hernández-Laín Aurelio, Palma Verónica, Gargini Ricardo, Sánchez-Gómez Pilar

Abstract excerpt

The extraordinary plasticity of glioma cells allows them to contribute to different cellular compartments in tumor vessels, reinforcing the vascular architecture. It was recently revealed that targeting glioma-derived pericytes, which represent a big percentage of the mural cell population in aggressive tumors, increases the permeability of the vessels and improves the efficiency of chemotherapy. However, the...

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PMID: 33593822
DOI: 10.1158/0008-5472.CAN-20-3558

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