Article

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis

2022-03-03

Abstract excerpt

<title>Abstract</title> <p>The outcome of infectious diseases may depend on the interaction between human and pathogen genomic variations. We explore this relationship in tuberculosis (TB) by conducting a genome-to-genome (g2g) study of paired genomes from humans and the infectious agent <italic>Mycobacterium tuberculosis</italic> (<italic>Mtb</italic>) in 1,556 Peruvian TB patients. We identified a significant a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7b5438d-cb48-5348-80db-8365f8c58a93
DOI: 10.21203/rs.3.rs-1397421/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosisDOI 10.21203/rs.3.rs-1397421/v1Read

A <i>FLOT1</i> host regulatory allele is associated with a recently expanded <i>Mtb</i> clade in patients with tuberculosisSemantic proximity Read

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.Semantic proximity Read

Genomic Interactions Between Mycobacterium tuberculosis and Humans.Semantic proximity Read

Human Genomics of Mycobacterium tuberculosis Infection and DiseaseSemantic proximity Read

An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

The Interplay of Human and Mycobacterium Tuberculosis Genomic VariabilitySemantic proximity Read

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from TanzaniaSemantic proximity Read

Interaction analysis of Mycobacterium tuberculosis between host environment and highly mutated genes from population genetic structure comparisonSemantic proximity Read

Within-host pathogen population diversity predicts treatment response in TuberculosisSemantic proximity Read

Genome graphs reveal the importance of structural variation in <i>Mycobacterium tuberculosis</i> evolution and drug resistanceSemantic proximity Read

Interaction between <em>M. tuberculosis</em> Lineage and Human Genetic Variants Reveals Novel Pathway Associations With Severity of TBSemantic proximity Read

Genome-wide host-pathogen analyses reveal genetic interaction points in tuberculosis diseaseSemantic proximity Read