Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.

doi:10.1038/s41467-024-54741-w

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Article

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.

Nature communications - 29 Nov 2024

Luo Yang, Huang Chuan-Chin, Howard Nicole C, Wang Xin, Liu Qingyun, Li Xinyi, Zhu Junhao, Amariuta Tiffany, Asgari Samira, Ishigaki Kazuyoshi, Calderon Roger, Raman Sahadevan, Ramnarine Alexandrea K, Mayfield Jacob A, Moody D Branch, Lecca Leonid, Fortune Sarah M, Murray Megan B, Raychaudhuri Soumya

Abstract excerpt

Infectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We conduct a genome-to-genome study of paired human and Mycobacterium tuberculosis genomes from a cohort of 1556 tuberculosis patients in Lima, Peru. We identify an association between a human intronic variant (rs3130660, OR = 10.06, 95%CI: 4.87 - 20.77, P = 7.92 × 10-8) in the FLOT1 gene and a...

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PMID: 39613754
DOI: 10.1038/s41467-024-54741-w
PMCID: PMC11607449

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FLOT1

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