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Mitochondrial double-stranded RNA accumulation in brain aging and Alzheimer’s disease

2026-02-04

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondria and inflammation are tightly linked in aging and Alzheimer’s disease (AD), and recent evidence implicates mitochondrial double-stranded RNA (mt-dsRNA) as a potential trigger of inflammation. We examined mt-dsRNA accumulation and dsRNA signaling in brain aging and AD using human brain tissue and complementary in vitro transcriptomic datasets, quantifying mitochondrial transcripts an...

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Literature Corpus work
e7a20c83-f1f1-5eb5-86e8-9c174bbcb2ca
DOI
10.64898/2026.02.02.703345
Open publication

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Mitochondrial double-stranded RNA accumulation in brain aging and Alzheimer’s diseaseDOI 10.64898/2026.02.02.703345
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