tRNA-derived fragments are elevated in the aging brain and may contribute to neurodegeneration

Abstract excerpt

tRNA-derived fragments (tRFs) are a class of small noncoding RNAs with emerging roles in stress responses and gene regulation, yet their dynamics across tissues and brain regions during aging remain poorly understood. Here, we systematically profiled age-associated changes in tRFs using three independent mouse small RNA-seq datasets spanning multiple organs and brain regions. Nuclear-encoded tRFs were the only sma...

Topics

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• Autophagy in Disease and Therapy
• Mitochondrial Function and Pathology
• RNA Research and Splicing

Identifiers and source

Literature Corpus work

67066dab-a56f-5949-a8dd-d1c293ecb962

DOI

10.64898/2026.05.15.725455