Article
The ontogenetic path of human dendritic cells.
Molecular immunology - 1 Apr 2020
Amon Lukas, Lehmann Christian H K, Heger Lukas, Heidkamp Gordon F, Dudziak Diana
Abstract excerpt
Dendritic cells (DCs) orchestrate adaptive immune responses. In healthy individuals, DCs are drivers and fine-tuners of T cell responses directed against invading pathogens or cancer cells. In parallel, DCs control autoreactive T cells, thereby maintaining T cell tolerance. Under various disease conditions, a disruption of this delicate balance can lead to chronic infections, tumor evasion, or autoimmunity. While...
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