Article

Multiome-seq links inflammatory bowel disease polygenic risk to TNF inhibitor response

2024-02-13

Abstract excerpt

Inflammatory Bowel Disease ( IBD ) is a chronic autoinflammatory disorder with rising incidence in pediatrics. TNFa inhibition ( TNFi ) is the first-line biologic therapy in children, but many do not achieve mucosal healing. Identifying which patients will benefit from TNFi and the underlying nonresponse mechanisms is critical. We built a novel resource: whole genome sequencing linked to multiome-seq (single-nuc...

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Literature Corpus work: e77f9988-6d57-5e17-8cf3-17af48e7f1cf
DOI: 10.1101/2024.02.09.579678

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