Article

Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

2021-09-22

Abstract excerpt

Crohn’s disease is an inflammatory bowel disease (IBD) commonly treated through anti-TNF blockade. However, most patients still relapse and inevitably progress. Comprehensive single-cell RNA-sequencing (scRNA-seq) atlases have largely sampled patients with established treatment-refractory IBD, limiting our understanding of which cell types, subsets, and states at diagnosis anticipate disease severity and response...

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Identifiers and source

Literature Corpus work: 80e307eb-7002-559f-845c-b86342540072
DOI: 10.1101/2021.09.17.21263540

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