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Breast tumor microenvironment structures are associated with genomic features and clinical outcome

18 Apr 2022

Abstract excerpt

The functions of the tumor microenvironment (TME) are orchestrated by precise spatial organization of specialized cells, yet little is known about the multicellular structures that form within the TME. Here we systematically mapped TME structures in situ using imaging mass cytometry and multitiered spatial analysis of 693 breast tumors linked to genomic and clinical data. We identified ten recurrent TME...

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PMID: 35437329
DOI: 10.1038/s41588-022-01041-y

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