Article

<i>BIRC5</i> dependency defines a targetable vulnerability in <i>TP53</i> mutant acute myeloid leukemia

2025-05-22

Abstract excerpt

<h4>ABSTRACT</h4> TP53 mutations across multiple cancers, including acute myeloid leukemia (AML), are associated with poor outcomes irrespective of treatment modality. However, druggable vulnerabilities beyond canonical p53 targets remain largely unexplored. We identify BIRC5 (encodes survivin), an inhibitor of the apoptosis protein (IAP) family, as a novel vulnerability in TP53 mutant AML using an unbiased, co...

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Literature Corpus work: fdb317ad-2d9e-51da-915a-8b1c8637bb8d
DOI: 10.1101/2025.05.17.654633

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