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TP53-based tripartite classification reveals three distinct mutation patterns across pan-cancer.

Cell reports - 26 May 2026

Ma Fayang, Dong Zigang

Abstract excerpt

We conducted a comprehensive pan-cancer analysis of gene mutation frequencies across 45,259 samples from 41,988 patients, which were classified into three categories: TP53_top, TP53_plus, and Non_TP53. Intersection analysis of mutated genes revealed heterogeneous overlaps among 61 cancers. Based on sample quantity, mutation frequency, and distribution patterns, 95 significantly mutated genes with 80,524 unique...

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PMID: 42139055
DOI: 10.1016/j.celrep.2026.117337

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TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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