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Persistent activation of STAT6 in keratinocytes elicits neutrophilic skin inflammation, pruritus and <i>S. aureus</i> colonization reminiscent of chronic atopic dermatitis

2026-02-05

Abstract excerpt

Atopic dermatitis (AD) evolves from initial type 2 immunity-driven inflammation to chronic mixed responses by poorly understood mechanisms. To investigate how the prolonged activation of the usually IL-4/IL-13-induced transcription factor STAT6 in keratinocytes impacts on the development and subtype of AD, we generated a new mouse model in which a constitutively active form of STAT6 is selectively expressed in ker...

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Identifiers and source

Literature Corpus work
e7153661-77c2-51b5-8679-70a8bfaec0eb
DOI
10.64898/2026.02.03.703471
Open publication

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Persistent activation of STAT6 in keratinocytes elicits neutrophilic skin inflammation, pruritus and <i>S. aureus</i> colonization reminiscent of chronic atopic dermatitisDOI 10.64898/2026.02.03.703471
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