Article
The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections.
The Journal of allergy and clinical immunology - 1 Nov 2011
Howell Michael D, Gao Peisong, Kim Byung Eui, Lesley Leighann J, Streib Joanne E, Taylor Patricia A, Zaccaro Daniel J, Boguniewicz Mark, Beck Lisa A, Hanifin Jon M, Schneider Lynda C, Hata Tissa R, Gallo Richard L, Kaplan Mark H, Barnes Kathleen C, Leung Donald Y M
Abstract excerpt
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with increased susceptibility to recurrent skin infections. OBJECTIVE: We sought to determine why a subset of patients with AD have an increased risk of disseminated viral skin infections. METHODS: Human subjects with AD with a history of eczema herpeticum (EH) and various control groups were enrolled. Vaccinia virus (VV)...
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